Mitochondrial Biology&Cellular Metal Ion Homeostasis


* denotes senior author papers; _ - denotes trainee author papers; # denotes co-first authors


  • Jett, K.A., Baker, Z.N., Hossain, A., Boulet, A., Cobine, P.A., Ghosh, S., Ng, P., Yilmaz, O., Barreto, K., DeCoteau, J., Mochoruk, K., Ioannou, G.N., Savard, C., Yuan, S., Abdalla, O.H., Lowden, C., Kim, B.E., Cheng, H.M., Battersby, B.J., Gohil, V.M., and Leary, S.C.* (2023) Mitochondrial dysfunction reactivates α-fetoprotein expression that drives copper-dependent immunosuppression in mitochondrial disease models. J. Clin. Invest. 133(1): e154684. doi: 10.1172/JCI154684.


  • Huang, J., Leary, S.C., and Xiang, J. (2022) Distinct strengths of mTORC1 control T-cell memory via transcriptional FOXO1 and metabolic AMPKα1 pathways in linear cell differentiation and asymmetric cell division models. Cell. Mol. Immunol. 19: 1073-1076.
  • Ara, A., Wu, Z., Xu, A., Ahmed, K.A., Leary, S.C., Islam, M.F., Chibbar, R., Wu, Y. and Xiang, J. (2022) The critical role of AMPKα1 in regulating autophagy and mitochondrial respiration in IL-15-stimulated mTORC1Weak signal-induced T cell memory: an interplay between Yin (AMPKα1) and Yang (mTORC1) energy sensors in T cell differentiation. Int. J. Mol. Sci. 23: 9534.
  • Xu, A., Leary, S.C., Islam, F., Wu, Z., Bhanumathy, K.K., Ara, A., Chibbar, R., Freywald, A., Ahmed, K.W. and Xiang, J. (2022) Pro-survival IL-7-stimulated weak strength of mTORC1-S6K controls T cell memory via transcriptional FOXO1-TCF1-Id3 and metabolic AMPKα1-ULK1-ATG7 pathways. J. Immunol. 208: 155-168.


  • Ara, A., Xu, A., Ahmed, K.A, Leary, S.C., Islam, F., Wu, Z., Chibbar, R. and Xiang, J. (2021) The energy sensor AMPKα1 is critical in rapamycin-inhibition of mTORC1-S6K-induced T-cell memory. Int. J. Mol. Sci. 23: 37.
  • Lowden, C., Boulet, A., Boehler, N.A., Seecharran, S., Garcia, J.R., Lowe, N.J., Liu, J., Ong, J.L.K., Wang, W., Ma, L., Cheng, A.H., Senatore, A., Monks, D.A., Liu, B.-h., Leary, S.C. and Cheng, H.-Y.M. (2021) Homeostatic control of nuclear-encoded mitochondrial gene expression by the histone variant H2A.Z is essential for neuronal survival. Cell Rep. 36: 1-16.
  • Zhu, X.#, Boulet, A.#, Buckley, K.M.#, Phillips, C.B., Gammon, M.G., Oldfather, L.E., Moore, S.A., Leary, S.C. and Cobine, P.A. (2021) Mitochondrial copper and phosphate transporter specificity was defined early in the evolution of eukaryotes. eLife Feb 16;10:e64690. doi: 10.7554/eLife.64690. Online ahead of print.
  • Quartey, M.O., Nyarko, J.N.K., Maley, J.M., Barnes, J.R., Bolanos, M.A.C., Heistad, R.M., Knudsen, K.J., Pennington, P.R., Buttigieg, J., De Carvalho, C.E., Leary, S.C., Parsons, M.P. and Mousseau, D.D. (2021) The Aβ(1-38) peptide is a negative regulator of the Aβ(1-42) peptide implicated in Alzheimer disease progression. Sci Rep. Jan 11;11(1):431. doi: 10.1038/s41598-020-80164-w.
  • Cobine, P.A.*, Moore, S.A. and Leary, S.C.* (2021) Getting out what you put in: Copper in mitochondria and its impacts on human disease. Biochim Biophys Acta Mol Cell Res. Jan;1868(1):118867. doi: 10.1016/j.bbamcr.2020.118867. Epub 2020 Oct 2.


  • Leary, S.C. and Ralle, M. (2020) Advances in visualization of copper in mammalian systems using X-ray fluorescence microscopy. Curr. Opin. Chem. Biol. 55: 19-25.


  • Soma, S., Morgada, M.N., Naik, M.T., Boulet, A., Roesler, A.A., Dziuba, N., Ghosh, A., Yu, Q., Lindahl, P.A., Ames, J.B., Leary, S.C., Vila, A.J. and Gohil, V.M. (2019) COA6 is structurally tuned to function as a thiol-disulfide oxidoreductase in copper delivery to mitochondrial cytochrome c oxidase. Cell Rep. 29: 4114-26.
  • Jin, W., Al-Dulaymi, M., Badea, I., Leary, S.C., Rehman, J. and El-Aneed, A. (2019) Cellular uptake and distribution of gemini surfactant nanoparticles used as gene delivery agents. AAPS J. 21: 98. dob: 10.1208/s12248-019-0367-1.
  • Jin, W., Badea, I., Leary, S.C. and El-Aneed, A. (2019) The determination of gemini surfactants used as gene delivery agents in cellular matrix using validated tandem mass spectrometric method. J Pharm Biomed Anal.164: 164-72.


  • Soma, S., Latimer, A.J., Chun, H., Vicary, A.C., Timbalia, S.A., Boulet, A., Rahn, J.J., Chan, S.S.L., Leary, S.C., Kim, B.E., Gitlin, J.D. and Gohil, V.M. (2018) Elesclomol restores mitochondrial function in genetic models of copper deficiency. Proc Natl Acad Sci USA 115: 8161-66.
  • Jett, K.A. and Leary, S.C.* (2018) Building the CuA site of cytochrome c oxidase: a complicated, redox-dependent process driven by a surprisingly large complient of accessory proteins. J Biol Chem 293: 4644-52.
  • Boulet, A.#, Vest, K.E.#, Maynard, M.K., Gammon, M.G., Russell, A.C., Mathews, A.T., Cole, S.E., Zhu, X., Phillips, C.B., Kwong, J.Q., Dodani, S.C., Leary, S.C., and Cobine, P.A. (2018) The mammalian phosphate carrier SLC25A3 is a mitochondrial copper transporter required for cytochrome c oxidase biogenesis. J Biol Chem 293: 1887-96.
  • Little, A.G., Lau, G., Mathers, K.E., Leary, S.C. and Moyes, C.D. (2018) Comparative biochiistry of cytochrome c oxidase in animals. Comp Biochi Physiol B (Biochi Mol Biol) 224: 170-84.


  • Baker, Z.N., Cobine, P.A. and Leary, S.C.* (2017) The mitochondrion: a central architect of copper homeostasis. Metallomics. 9: 1501-12.
  • Baker, Z.N., Jett, K., Boulet, A., Hossain, A., Cobine, P.A., Kim, B.E., El Zawily, A.M., Lee, L., Tibbits, G.F., Petris, M.J. and Leary, S.C.* (2017) The mitochondrial metallochaperone SCO1 maintains CTR1 at the plasma membrane to preserve copper homeostasis in the murine heart. Hum Mol Genet. 26: 4617-28.